Platelet-Rich Fibrin Matrix (PRFM) vs Platelet-Rich Plasma (PRP) – Advanced Microneedling
Microneedling already works by creating controlled microchannels that trigger the skin’s natural repair response. Adding a platelet-based treatment takes that concept a step further. If you are comparing Platelet-Rich Fibrin Matrix (PRFM) vs Platelet-Rich Plasma (PRP) – advanced microneedling, the biggest difference is what happens to the platelets after your blood is processed.
Traditional PRP suspends concentrated platelets in plasma, while PRFM adds a fibrin matrix designed to hold those platelets in place and support a more gradual release of growth factors. Lords & Ladies Salon and Medical Spa offers advanced microneedling with PRFM for clients interested in combining SkinPen treatment with their own platelet-rich material.
What Happens During Microneedling?
Microneedling uses very fine needles to create controlled micro-injuries in the skin.
Those tiny channels start a normal wound-healing response that involves collagen remodeling. SkinPen, the microneedling device used by Lords & Ladies, is FDA-cleared for improving the appearance of facial acne scars in adults aged 22 and older across all Fitzpatrick skin types. It is also cleared for improving the appearance of neck wrinkles in certain skin types.
Microneedling can be performed on its own.
PRFM is an optional enhancement that uses material prepared from your own blood during the same treatment visit.
What Is Platelet-Rich Plasma?
PRP stands for platelet-rich plasma.
A small blood sample is drawn and placed into a centrifuge. The spinning process separates components of the blood so that platelet-rich plasma can be collected.
Platelets are best known for their role in clotting, but they also release signaling proteins known as growth factors that participate in the body’s repair processes.
Traditional PRP treatments use the concentrated platelet-containing plasma relatively soon after preparation.
The concept has been used in several areas of medicine and aesthetics, including skin rejuvenation and hair-restoration procedures.
What Makes PRFM Different?
PRFM starts with PRP, but the preparation continues one step further.
With the SELPHYL® system, PRP is converted into a platelet-rich fibrin matrix through fibrin polymerization. The resulting three-dimensional fibrin structure acts as a scaffold around the platelets. That scaffold is the key distinction.
Rather than platelets simply remaining suspended in liquid plasma, PRFM holds them within a fibrin network at the treatment area.
According to SELPHYL, laboratory and clinical research associated with its system has shown platelet growth-factor release for up to seven days after preparation. Traditional PRP generally releases those factors over a shorter period.
That does not mean PRFM automatically produces better results for every person. Individual response, treatment technique, skin condition, and treatment goals all matter.
How Is PRFM Used With Microneedling?
At Lords & Ladies, PRFM can be combined with microneedling as an advanced skin-rejuvenation treatment.
The process begins with the blood draw and preparation of the platelet-rich material. Microneedling is then performed with SkinPen, creating controlled microchannels in the treatment area. PRFM is applied during or following the procedure as directed by the medical provider. Lords & Ladies describes the combination as a way to support collagen production, healing, texture, and tone.
Because blood processing is involved, PRFM microneedling at Lords & Ladies must be scheduled with one of the salon’s nurse injectors.
Is PRFM the Same as PRF?
Not exactly. The terms PRP, PRF, and PRFM are sometimes used interchangeably online, which can make things confusing.
PRP is platelet-rich plasma.
PRF generally refers to platelet-rich fibrin, which also uses a fibrin network but is prepared differently.
PRFM specifically means platelet-rich fibrin matrix. SELPHYL describes PRFM as a further refinement of platelet-rich therapies in which the platelets and growth factors are localized within a structured fibrin scaffold.
For clients, the practical question is less about memorizing the acronyms and more about understanding exactly which system a provider uses and why.
What Skin Concerns Can Advanced Microneedling Address?
Microneedling is commonly chosen by people concerned about uneven texture, acne scarring, or visible changes associated with aging.
SkinPen’s formal FDA-cleared indications are more specific: facial acne scars in adults age 22 and older and neck wrinkles within the cleared patient population.
Lords & Ladies combines PRFM with microneedling as a rejuvenation option for clients interested in improving the overall look and feel of their skin. Because PRFM comes from your own blood, it does not introduce a synthetic filler into the treated area.
Results develop gradually rather than appearing overnight. Your body still has to complete the remodeling process.
Is There Downtime After PRFM Microneedling?
Some temporary redness and sensitivity are expected after microneedling.
The skin may look similar to a mild sunburn for a short period, and swelling, tightness, or dryness can occur. Individual reactions differ.
Your provider will give you treatment-specific aftercare instructions. In general, it is important to avoid introducing irritating active ingredients too quickly and to protect recently treated skin from excessive sun exposure.
Do not schedule an unfamiliar advanced skin treatment the day before an important event. Give your skin time to settle.
Which Is Better: PRFM or PRP?
There is no universal answer. Both begin with your own blood and concentrate platelets for use in a treatment area. PRFM differs by placing those platelets in a fibrin matrix designed to localize them and extend growth-factor release.
For Lords & Ladies clients, PRFM is the advanced platelet-based option currently offered with microneedling. A consultation with a nurse injector can help determine whether adding it makes sense based on your skin, medical history, previous treatments, and goals.
Learn More About Advanced PRFM Microneedling at Lords & Ladies
When comparing Platelet-Rich Fibrin Matrix (PRFM) vs Platelet-Rich Plasma (PRP) – Advanced Microneedling, the main difference is the fibrin scaffold that transforms PRP into PRFM and keeps platelets localized for a more sustained release of growth factors.
Lords & Ladies Salon and Medical Spa offers SkinPen microneedling with PRFM through its trained nurse injectors for clients who want to explore this advanced approach to skin rejuvenation. Call 1-844-725-6655 or schedule a complimentary consultation with Lords & Ladies to find out whether PRFM microneedling fits your skincare goals.